DTL

Across TCGA pan-cancer cohorts, DTL RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of DTL’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where DTL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DTL is over-expressed in tumor.

BLCA, HNSC, and KIRC are the cancer types where DTL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DTL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Female	All	+2.596	<.001	12	view →
HNSC	Male	All	+2.193	<.001	12	view →
KIRC	Male	All	+1.637	<.001	12	view →
KIRP	All	IV	+2.802	<.001	11	view →
LUAD	Male	III,IV	+2.474	<.001	11	view →
COAD	Female	II,III,IV	+1.380	<.001	10	view →
STAD	Female	All	+2.297	<.001	9	view →
LIHC	Female	II,III,IV	+2.206	<.001	9	view →
THCA	Male	All	+0.739	<.001	9	view →
LUSC	Female	II,III,IV	+2.810	<.001	8	view →
READ	All	All	+1.454	<.001	7	view →
UCEC	All	III,IV	+2.986	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

DTL–BLCA

Open the BLCA breakdown →