DTL

Across TCGA patient cohorts, DTL mutation is significantly associated with the RNA expression of many other genes, with 1,194 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTL-associated genes across cancer lineages are RN7SL763P, TRAJ43, and ZDHHC7. Each is linked with DTL in more than 1 cancer types. Because this analysis shows association rather than direction, both DTL-to-partner and partner-to-DTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL763P grouped by DTL-low versus DTL-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTL→partner) and Y-score (partner→DTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RN7SL763P →	+0.138	+5.187	<.001	.007	3	2
BLCA	TRAJ43 →	+0.619	+4.588	<.001	.008	3	2
UCEC	ZDHHC7 →	+0.423	+3.608	.001	.001	3	2
UCEC	MPPE1 →	+0.427	+2.329	.002	.003	3	2
UCEC	MFSD12 →	+0.432	+2.280	.003	.001	3	2
UCEC	MON1A →	+0.419	+3.711	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,194 associations by consensus.

RN7SL763P by DTL expression — STAD

Explore this box plot interactively →