DTL

Across TCGA cell cohorts, DTL RNA expression is significantly associated with the go_rna of many other GO terms, with 4,686 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DTL-associated GO terms across cancer lineages are Regulation of DNA-templated DNA replication initiation, Chromosome condensation, and DNA replication. Each is linked with DTL in more than 19 cancer types. Because this analysis shows association rather than direction, both DTL-to-partner and partner-to-DTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated DNA replication initiation grouped by DTL-low versus DTL-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DTL→partner) and Y-score (partner→DTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of DNA-templated DNA replication initiation →	+0.160	+1.328	<.001	.001	3	20
OESOPHAGUS	Chromosome condensation →	+0.204	+1.638	<.001	<.001	3	20
OESOPHAGUS	DNA replication →	+0.131	+1.507	<.001	<.001	3	20
OESOPHAGUS	Chromosome segregation →	+0.128	+1.701	<.001	<.001	3	20
BONE	Centriole assembly →	+0.139	+1.806	<.001	.002	3	19
OESOPHAGUS	Meiotic chromosome condensation →	+0.184	+1.013	.001	.003	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,686 associations by consensus.

Regulation of DNA-templated DNA replication initiation by DTL expression — KIDNEY

Explore this box plot interactively →