DTL

Across TCGA cell cohorts, DTL mutation is significantly associated with the drug of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DTL-associated genes across cancer lineages are Entospletinib, PRT062607, and KRAS (G12C) Inhibitor-12. Each is linked with DTL in more than 1 cancer types. Because this analysis shows association rather than direction, both DTL-to-partner and partner-to-DTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Entospletinib grouped by DTL-low versus DTL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTL→partner) and Y-score (partner→DTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Entospletinib →	+0.395	+2.646	.039	.047	3	1
LARGE_INTESTINE	PRT062607 →	+0.600	+2.777	.017	.030	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.604	+2.646	.014	.047	3	1
LARGE_INTESTINE	Teniposide →	+0.692	+2.649	.008	.046	2	1
LARGE_INTESTINE	Voxtalisib →	+0.291	+2.652	.038	.045	2	1
LARGE_INTESTINE	Nutlin-3a (-) →	+0.835	+2.646	.022	.047	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Entospletinib by DTL expression — LARGE_INTESTINE

Explore this box plot interactively →