DSTYK

Across TCGA patient cohorts, DSTYK mutation is significantly associated with the RNA expression of many other genes, with 1,910 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSTYK-associated genes across cancer lineages are ZNF367, TMEM11, and ATP2A3. Each is linked with DSTYK in more than 1 cancer types. Because this analysis shows association rather than direction, both DSTYK-to-partner and partner-to-DSTYK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF367 grouped by DSTYK-low versus DSTYK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSTYK→partner) and Y-score (partner→DSTYK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF367 →	+0.726	+2.201	<.001	<.001	3	2
UCEC	TMEM11 →	+0.301	+2.617	.003	<.001	3	2
UCEC	ATP2A3 →	+0.983	+1.595	<.001	.006	3	2
UCEC	ALKBH5 →	+0.527	+2.436	<.001	.001	3	2
BLCA	LINC00533 →	+0.269	+3.735	<.001	.005	3	2
BLCA	LINC02077 →	+0.229	+5.040	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,910 associations by consensus.

ZNF367 by DSTYK expression — UCEC

Explore this box plot interactively →