DSTYK

Across TCGA pan-cancer cohorts, DSTYK RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DSTYK data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher DSTYK RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DSTYK expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

BLCA, KIRC, and ACC are the cancer types where DSTYK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	II,III,IV	0.264	0.401	<.001	97	view →
KIRC	DFS	Median	All	0.727	0.543	<.001	84	view →
ACC	DFS	Tertile	All	0.374	0.810	<.001	44	view →
CESC	DFS	Tertile	All	0.755	0.885	.001	36	view →
UVM	DFS	Median	III,IV	0.208	0.740	.006	36	view →
UCEC	DFS	Quartile	All	0.642	0.786	.004	28	view →
LGG	DFS	Median	All	0.873	0.787	<.001	23	view →
KICH	OS	Quartile	II,III,IV	0.600	1.000	.018	17	view →
LIHC	OS	Median	All	0.703	0.858	<.001	17	view →
GBM	DFS	Median	All	0.388	0.181	.001	14	view →
STAD	DFS	Quartile	All	0.355	0.616	.016	9	view →
CHOL	DFS	Median	All	0.727	0.227	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DSTYK–BLCA (DFS)

Open the BLCA breakdown →