DSTYK

Across TCGA patient cohorts, DSTYK mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSTYK-associated genes across cancer lineages are FoxM1, Acetyl-a-Tubulin-Lys40, and INPP4B. Each is linked with DSTYK in more than 2 cancer types. Because this analysis shows association rather than direction, both DSTYK-to-partner and partner-to-DSTYK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by DSTYK-low versus DSTYK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSTYK→partner) and Y-score (partner→DSTYK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.253	+1.847	.007	.008	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.425	+1.502	.023	.030	3	2
UCEC	INPP4B →	-0.303	-2.584	.010	.010	3	2
UCEC	MSH2 →	-0.169	-2.295	.046	.033	3	2
UCEC	p27_pT198 →	+0.093	+2.321	.018	.034	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.366	-2.999	.027	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

FoxM1 by DSTYK expression — UCEC

Explore this box plot interactively →