DSTYK

Across TCGA cell cohorts, DSTYK mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DSTYK-associated genes across cancer lineages are TEX43, ZIM3, and TBL1Y. Each is linked with DSTYK in more than 1 cancer types. Because this analysis shows association rather than direction, both DSTYK-to-partner and partner-to-DSTYK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX43 grouped by DSTYK-low versus DSTYK-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSTYK→partner) and Y-score (partner→DSTYK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TEX43 →	+0.105	+4.969	<.001	.003	3	2
PANCREAS	ZIM3 →	+0.005	+4.614	<.001	.004	3	1
PANCREAS	TBL1Y →	+0.005	+4.614	<.001	.004	3	1
BONE	OR1L6 →	+0.015	+4.169	<.001	.008	3	1
BONE	OR52N1 →	+0.011	+4.307	.009	.004	3	1
BONE	C2orf80 →	+0.095	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

TEX43 by DSTYK expression — BLOOD_Leukemia

Explore this box plot interactively →