DST

Across TCGA pan-cancer cohorts, DST Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated DST data layer compared with 20 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher DST Mutation is associated with better overall survival. In most high-consensus cancer types, elevated DST expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

BLCA, THYM, and UCEC are the cancer types where DST Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	II,III,IV	0.691	0.375	<.001	48	view →
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	OS	Median	All	0.857	0.615	<.001	36	view →
ACC	DFS	Median	IV	0.012	0.310	.002	16	view →
COAD	OS	Median	IV	0.045	0.659	<.001	12	view →
STAD	OS	Median	III,IV	0.831	0.601	.013	10	view →
LUAD	DFS	Median	All	0.863	0.778	.036	6	view →
GBM	OS	Median	All	0.117	0.419	.002	3	view →
ESCA	DFS	Median	III,IV	0.210	0.450	.015	3	view →
HNSC	DFS	Median	II,III,IV	0.746	0.323	.031	2	view →
SKCM	OS	Median	III,IV	0.545	0.725	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

DST–BLCA (OS)

Open the BLCA breakdown →