DST

Across TCGA pan-cancer cohorts, DST RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DST’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DST RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DST is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

HNSC, COAD, and LUAD are the cancer types where DST tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DST RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.095	<.001	11	view →
COAD	Female	All	−1.121	<.001	7	view →
LUAD	Female	All	−0.972	<.001	7	view →
BRCA	All	III,IV	−2.499	<.001	6	view →
UCEC	All	All	−1.843	<.001	6	view →
BLCA	Male	All	−1.699	<.001	5	view →
STAD	Female	All	−1.651	.005	3	view →
CHOL	All	All	+1.612	<.001	3	view →
READ	Female	All	−1.310	<.001	2	view →
LIHC	Female	II,III,IV	+0.746	.023	2	view →
PRAD	All	All	−0.654	<.001	2	view →
LUSC	Male	All	+0.517	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DST–HNSC

Open the HNSC breakdown →