DST

Across TCGA pan-cancer cohorts, DST mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DST data layer compared with 20 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DST mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DST expression acts as an unfavorable survival marker, although some lineages such as COAD and HNSC show a favorable association.

CCRCC, COAD, and LUAD are the cancer types where DST mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.235	0.887	.005	22	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.903	.036	12	view →
LUAD	OS	Quartile	II,III,IV	0.270	1.000	.020	8	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.884	.010	4	view →
UCEC	OS	Median	III,IV	0.554	0.884	.045	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DST–CCRCC (DFS)

Open the CCRCC breakdown →