DST

Across TCGA patient cohorts, DST mutation is significantly associated with the RNA expression of many other genes, with 9,616 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DST-associated genes across cancer lineages are NCAPG, SKA1, and NIPA1. Each is linked with DST in more than 6 cancer types. Because this analysis shows association rather than direction, both DST-to-partner and partner-to-DST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPG grouped by DST-low versus DST-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DST→partner) and Y-score (partner→DST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPG →	+0.491	+0.854	<.001	<.001	3	7
UCEC	SKA1 →	+0.502	+1.214	<.001	<.001	3	7
UCEC	NIPA1 →	+0.621	+1.553	<.001	<.001	3	7
STAD	FAM136A →	+0.306	+2.535	.002	<.001	3	6
STAD	PRC1 →	+0.482	+1.736	.004	.005	3	6
COAD	KIF23 →	+0.288	+1.453	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,616 associations by consensus.

NCAPG by DST expression — UCEC

Explore this box plot interactively →