DST

Across TCGA patient cohorts, DST mutation is significantly associated with the total protein of many other genes, with 133 significant associations in total. COAD shows the largest number of these associations.

The most reproducible DST-associated genes across cancer lineages are mTOR_pS2448, ASNS, and Caspase-7-cleavedD198. Each is linked with DST in more than 4 cancer types. Because this analysis shows association rather than direction, both DST-to-partner and partner-to-DST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by DST-low versus DST-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DST→partner) and Y-score (partner→DST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	mTOR_pS2448 →	-0.114	-1.830	.010	.006	3	5
COAD	ASNS →	+0.318	+1.514	.001	.010	3	5
COAD	Caspase-7-cleavedD198 →	+0.884	+2.476	<.001	<.001	3	5
LUAD	FOXO3a_pS318_S321 →	-0.081	-1.857	.002	.001	3	4
LUAD	MIG-6 →	+0.117	+1.864	.023	.003	3	4
UCEC	STAT3_pY705 →	-0.189	-0.758	<.001	.014	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 133 associations by consensus.

mTOR_pS2448 by DST expression — COAD

Explore this box plot interactively →