DST

Across TCGA cell cohorts, DST RNA expression is significantly associated with the go_rna of many other GO terms, with 5,402 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DST-associated GO terms across cancer lineages are Regulation of focal adhesion assembly, Regulation of cell-substrate junction assembly, and Positive regulation of supramolecular fiber organization. Each is linked with DST in more than 12 cancer types. Because this analysis shows association rather than direction, both DST-to-partner and partner-to-DST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of focal adhesion assembly grouped by DST-low versus DST-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DST→partner) and Y-score (partner→DST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of focal adhesion assembly →	+0.163	+2.191	<.001	<.001	3	13
BONE	Regulation of cell-substrate junction assembly →	+0.163	+2.191	<.001	<.001	3	13
BONE	Positive regulation of supramolecular fiber organization →	+0.083	+2.678	<.001	<.001	3	13
BONE	Regulation of cell-matrix adhesion →	+0.140	+2.240	<.001	<.001	3	13
BONE	Positive regulation of cellular response to transforming growth factor beta stimulus →	+0.116	+2.506	.001	<.001	3	13
BONE	Positive regulation of transforming growth factor beta receptor signaling pathway →	+0.116	+2.506	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,402 associations by consensus.

Regulation of focal adhesion assembly by DST expression — BONE

Explore this box plot interactively →