DST

Across TCGA cell cohorts, DST mutation is significantly associated with the RNA expression of many other genes, with 3,045 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DST-associated genes across cancer lineages are CCNF, PRMT7, and BUB3. Each is linked with DST in more than 4 cancer types. Because this analysis shows association rather than direction, both DST-to-partner and partner-to-DST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNF grouped by DST-low versus DST-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DST→partner) and Y-score (partner→DST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CCNF →	+0.941	+3.074	<.001	.008	3	4
LARGE_INTESTINE	PRMT7 →	+0.570	+3.321	.002	.002	3	4
BLOOD_Leukemia	BUB3 →	+0.434	+1.553	.003	.001	3	4
BLOOD_Leukemia	ANKRD39 →	+0.331	+2.230	.002	.002	3	4
CNS	C1orf35 →	+0.414	+2.291	.006	.002	3	4
LARGE_INTESTINE	TRIT1 →	+0.548	+1.566	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,045 associations by consensus.

CCNF by DST expression — OVARY

Explore this box plot interactively →