DSN1

Across TCGA pan-cancer cohorts, DSN1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DSN1 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher DSN1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DSN1 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, LUAD, and HNSC are the cancer types where DSN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.868	.035	18	view →
LUAD	DFS	Quartile	III,IV	0.960	0.264	.006	16	view →
HNSC	DFS	Quartile	All	0.176	0.947	.017	12	view →
PDAC	DFS	Median	All	0.424	0.211	.008	9	view →
LSCC	OS	Quartile	All	0.884	0.714	.026	8	view →
CCRCC	OS	Median	All	0.713	1.000	.010	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DSN1–COAD (DFS)

Open the COAD breakdown →