DSG4

Across TCGA patient cohorts, DSG4 RNA expression is significantly associated with the RNA expression of many other genes, with 10,721 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible DSG4-associated genes across cancer lineages are DSC2, DSG1, and DSG1-AS1. Each is linked with DSG4 in more than 16 cancer types. Because this analysis shows association rather than direction, both DSG4-to-partner and partner-to-DSG4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DSG4 versus DSC2 in CESC, with a Pearson correlation of 0.36.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG4→partner) and Y-score (partner→DSG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	DSC2 →	+2.045	+0.553	<.001	<.001	3	17
HNSC	DSG1 →	+3.104	+0.306	<.001	<.001	3	16
CESC	DSG1-AS1 →	+2.235	+0.361	<.001	<.001	3	15
HNSC	DSC1 →	+1.643	+0.331	<.001	<.001	3	15
ESCA	LRATD1 →	+1.640	+0.331	<.001	<.001	3	14
READ	TRAPPC8 →	+0.566	+0.393	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,721 associations by consensus.

DSG4 vs DSC2 — CESC

Explore this scatter interactively →