DSG2

Across TCGA patient cohorts, DSG2 protein abundance is significantly associated with the RNA expression of many other genes, with 16,712 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DSG2-associated genes across cancer lineages are DSG2-AS1, MFNG, and PIK3CG. Each is linked with DSG2 in more than 7 cancer types. Because this analysis shows association rather than direction, both DSG2-to-partner and partner-to-DSG2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DSG2 versus DSG2-AS1 in LSCC, with a Pearson correlation of 0.75.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSG2→partner) and Y-score (partner→DSG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DSG2-AS1 →	+0.787	+0.669	<.001	<.001	3	8
OV	MFNG →	-0.910	-0.604	.001	<.001	3	7
OV	PIK3CG →	-1.073	-0.745	<.001	<.001	3	7
OV	BTK →	-1.092	-0.556	<.001	<.001	3	7
LSCC	SLAMF1 →	-0.662	-0.454	<.001	<.001	3	7
OV	MAN1C1 →	-0.890	-0.637	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,712 associations by consensus.

DSG2 vs DSG2-AS1 — LSCC

Explore this scatter interactively →