DSG2-AS1

Across TCGA pan-cancer cohorts, DSG2-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated DSG2-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher DSG2-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated DSG2-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and BRCA show a favorable association.

KIRP, LGG, and ESCA are the cancer types where DSG2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	All	0.948	0.760	<.001	55	view →
LGG	OS	Tertile	All	0.703	0.834	<.001	33	view →
ESCA	OS	Median	IV	0.222	0.698	.006	29	view →
LUAD	OS	Median	All	0.779	0.886	.004	26	view →
LIHC	OS	Quartile	All	0.635	0.841	.001	26	view →
SARC	DFS	Quartile	All	0.226	0.529	.001	25	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	24	view →
BRCA	OS	Tertile	All	0.978	0.942	.010	21	view →
PAAD	OS	Median	II,III,IV	0.467	0.637	.017	15	view →
CESC	OS	Median	All	0.453	0.685	.019	10	view →
STAD	DFS	Tertile	IV	0.252	0.863	.030	9	view →
DLBC	DFS	Tertile	III,IV	0.137	0.761	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

DSG2-AS1–KIRP (OS)

Open the KIRP breakdown →