DSG2-AS1

Across TCGA pan-cancer cohorts, DSG2-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of DSG2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DSG2-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DSG2-AS1 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

HNSC, COAD, and KICH are the cancer types where DSG2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DSG2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.481	<.001	11	view →
COAD	Male	All	−0.358	<.001	9	view →
KICH	All	II,III,IV	+0.611	<.001	6	view →
STAD	All	II,III,IV	+0.352	.001	6	view →
UCEC	All	All	+0.306	.001	6	view →
BRCA	All	III,IV	−0.253	<.001	6	view →
LUSC	Male	All	+0.378	<.001	5	view →
BLCA	All	III,IV	+0.329	.011	5	view →
LIHC	All	II,III,IV	−0.156	.025	3	view →
CHOL	All	All	+0.618	.010	2	view →
KIRP	All	All	+0.163	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

DSG2-AS1–HNSC

Open the HNSC breakdown →