DSG1-AS1

Across TCGA pan-cancer cohorts, DSG1-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated DSG1-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher DSG1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DSG1-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and CESC show a favorable association.

ACC, KICH, and THCA are the cancer types where DSG1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.326	0.692	.004	75	view →
KICH	OS	Tertile	All	0.082	0.877	<.001	60	view →
THCA	OS	Tertile	IV	0.846	1.000	.003	45	view →
LUSC	DFS	Quartile	II,III,IV	0.810	0.563	<.001	43	view →
BLCA	DFS	Tertile	All	0.270	0.426	.012	26	view →
LUAD	OS	Tertile	All	0.203	0.404	.006	18	view →
LGG	DFS	Tertile	All	0.156	0.460	.001	12	view →
GBM	DFS	Tertile	All	0.061	0.288	<.001	9	view →
CESC	DFS	Tertile	All	0.889	0.773	.010	8	view →
LIHC	OS	Tertile	II,III,IV	0.461	0.673	.022	8	view →
THYM	OS	Median	II,III,IV	0.734	1.000	.021	6	view →
TGCT	DFS	Median	II,III,IV	0.750	0.996	.046	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

DSG1-AS1–ACC (DFS)

Open the ACC breakdown →