DSG1-AS1

Across TCGA pan-cancer cohorts, DSG1-AS1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of DSG1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DSG1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types DSG1-AS1 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

HNSC, LUSC, and BLCA are the cancer types where DSG1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DSG1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−1.227	<.001	10	view →
LUSC	Female	II,III,IV	+2.527	<.001	7	view →
BLCA	All	IV	+1.097	.005	4	view →
COAD	All	All	+0.258	.002	4	view →
BRCA	All	II,III,IV	+0.113	.027	3	view →
LUAD	All	All	+0.119	.013	2	view →
LIHC	All	All	+0.037	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

DSG1-AS1–HNSC

Open the HNSC breakdown →