DSEL

Across TCGA patient cohorts, DSEL mutation is significantly associated with the RNA expression of many other genes, with 6,320 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSEL-associated genes across cancer lineages are PBK, CDKN3, and PSMA3. Each is linked with DSEL in more than 4 cancer types. Because this analysis shows association rather than direction, both DSEL-to-partner and partner-to-DSEL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PBK grouped by DSEL-low versus DSEL-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSEL→partner) and Y-score (partner→DSEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PBK →	+0.809	+3.278	<.001	<.001	3	5
UCEC	CDKN3 →	+0.653	+1.595	<.001	<.001	3	4
COAD	PSMA3 →	+0.391	+2.937	<.001	<.001	2	5
UCEC	NCAPG →	+0.669	+1.595	<.001	<.001	3	4
COAD	MRPS15 →	+0.311	+3.388	.005	.004	3	4
UCEC	DLGAP5 →	+0.569	+1.332	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,320 associations by consensus.

PBK by DSEL expression — COAD

Explore this box plot interactively →