DSEL

Across TCGA pan-cancer cohorts, DSEL RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DSEL’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DSEL RNA is repressed in tumor relative to normal tissue. In most cancer types DSEL is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and UCEC are the cancer types where DSEL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DSEL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.581	<.001	10	view →
THCA	Male	II,III,IV	−0.723	<.001	9	view →
UCEC	All	III,IV	−1.665	<.001	8	view →
LUSC	Female	II,III,IV	−1.190	<.001	6	view →
BRCA	Female	All	−0.878	<.001	6	view →
KIRC	Male	All	+0.744	<.001	6	view →
LUAD	All	All	−0.347	.002	6	view →
KICH	Female	All	−1.376	<.001	5	view →
BLCA	All	All	−0.617	.009	5	view →
CHOL	All	All	+1.821	<.001	3	view →
HNSC	Female	All	+0.448	.033	3	view →
READ	All	All	−0.872	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DSEL–COAD

Open the COAD breakdown →