DSEL

Across TCGA patient cohorts, DSEL mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSEL-associated genes across cancer lineages are 4E-BP1, MAPK_pT202_Y204, and ASNS. Each is linked with DSEL in more than 3 cancer types. Because this analysis shows association rather than direction, both DSEL-to-partner and partner-to-DSEL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by DSEL-low versus DSEL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSEL→partner) and Y-score (partner→DSEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.317	+1.584	<.001	<.001	3	4
COAD	MAPK_pT202_Y204 →	-0.565	-3.321	.001	.009	3	3
COAD	ASNS →	+0.389	+2.321	.008	.033	3	3
LUSC	c-Myc →	-0.178	-3.169	.036	.017	3	2
SKCM	JNK2 →	-0.182	-1.982	.047	.031	3	2
COAD	A-Raf_pS299 →	-0.157	-3.152	.012	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

4E-BP1 by DSEL expression — UCEC

Explore this box plot interactively →