DSEL

Across TCGA cell cohorts, DSEL mutation is significantly associated with the RNA expression of many other genes, with 836 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DSEL-associated genes across cancer lineages are UTF1, SAMM50, and SDC4. Each is linked with DSEL in more than 1 cancer types. Because this analysis shows association rather than direction, both DSEL-to-partner and partner-to-DSEL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UTF1 grouped by DSEL-low versus DSEL-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSEL→partner) and Y-score (partner→DSEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	UTF1 →	+0.136	+4.643	<.001	.008	3	2
LARGE_INTESTINE	SAMM50 →	+0.492	+2.523	.001	.003	3	2
LARGE_INTESTINE	SDC4 →	-0.981	-2.571	.008	.002	3	2
LARGE_INTESTINE	SSR1 →	+0.739	+2.459	<.001	.006	3	2
LARGE_INTESTINE	METTL16 →	+0.567	+3.850	<.001	<.001	3	2
LARGE_INTESTINE	GPD1L →	+0.798	+2.743	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 836 associations by consensus.

UTF1 by DSEL expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →