DSE

Across TCGA cell cohorts, DSE mutation is significantly associated with the RNA expression of many other genes, with 249 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DSE-associated genes across cancer lineages are AVP, C16orf92, and C10orf95. Each is linked with DSE in more than 2 cancer types. Because this analysis shows association rather than direction, both DSE-to-partner and partner-to-DSE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by DSE-low versus DSE-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSE→partner) and Y-score (partner→DSE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AVP →	+1.335	+3.855	.009	.007	3	3
SOFT_TISSUE	C16orf92 →	+0.028	+4.635	.004	.003	3	2
BLOOD_Lymphoma	C10orf95 →	+0.475	+3.459	<.001	.003	3	2
BLOOD_Lymphoma	OR2D2 →	+0.035	+2.700	<.001	.001	3	2
LARGE_INTESTINE	C1QBP →	+0.752	+3.451	.001	.002	3	2
PANCREAS	OR14A2 →	+0.020	+5.614	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 249 associations by consensus.

AVP by DSE expression — BLOOD_Leukemia

Explore this box plot interactively →