Across TCGA pan-cancer cohorts, DSCR4 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of DSCR4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DSCR4 RNA is repressed in tumor relative to normal tissue. In most cancer types DSCR4 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

KIRC, LIHC, and STAD are the cancer types where DSCR4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DSCR4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.012	.006	5	view →
LIHC	All	All	+0.305	.007	4	view →
STAD	All	All	+0.318	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: DSCR4 RNA expression & survival · all DSCR4 data types