DSCR10

Across TCGA patient cohorts, DSCR10 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DSCR10-associated genes across cancer lineages are MYH11, PKC-b-II_pS660, and PREX1. Each is linked with DSCR10 in more than 1 cancer types. Because this analysis shows association rather than direction, both DSCR10-to-partner and partner-to-DSCR10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH11 grouped by DSCR10-low versus DSCR10-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSCR10→partner) and Y-score (partner→DSCR10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MYH11 →	-1.063	-3.169	.013	.018	3	1
SKCM	PKC-b-II_pS660 →	+0.312	+2.321	.032	.035	3	1
SKCM	PREX1 →	+0.320	+2.339	.049	.019	3	1
UCEC	Tuberin →	+0.347	+3.179	.019	.010	3	1
SKCM	Collagen-VI →	-0.344	-2.321	.045	.035	2	1
SKCM	HER3 →	+0.472	+3.476	.021	.002	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MYH11 by DSCR10 expression — SKCM

Explore this box plot interactively →