DSCR10

Across TCGA pan-cancer cohorts, DSCR10 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated DSCR10 data layer compared with 5 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher DSCR10 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DSCR10 expression acts as an unfavorable survival marker, although some lineages such as GBM and SKCM show a favorable association.

UVM, STAD, and KIRC are the cancer types where DSCR10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	II,III,IV	0.213	0.718	.002	81	view →
STAD	OS	Quartile	II,III,IV	0.199	0.433	.003	78	view →
KIRC	OS	Tertile	II,III,IV	0.687	0.815	.023	54	view →
LIHC	OS	Tertile	II,III,IV	0.435	0.648	.003	45	view →
THYM	OS	Tertile	II,III,IV	0.767	1.000	.002	42	view →
LAML	DFS	Tertile	All	0.144	0.405	.006	36	view →
LUAD	OS	Tertile	II,III,IV	0.585	0.732	.008	33	view →
READ	DFS	Tertile	IV	0.190	0.638	.008	27	view →
COAD	OS	Tertile	IV	0.159	0.570	.014	27	view →
GBM	DFS	Tertile	All	0.654	0.220	.010	18	view →
KIRP	DFS	Tertile	II,III,IV	0.122	0.626	.032	18	view →
PCPG	DFS	Tertile	All	0.795	0.926	.007	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

DSCR10–UVM (OS)

Open the UVM breakdown →