DSCAM

Across TCGA patient cohorts, DSCAM mutation is significantly associated with the RNA expression of many other genes, with 8,831 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSCAM-associated genes across cancer lineages are KIF4A, UHRF1, and CDKN3. Each is linked with DSCAM in more than 6 cancer types. Because this analysis shows association rather than direction, both DSCAM-to-partner and partner-to-DSCAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF4A grouped by DSCAM-low versus DSCAM-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSCAM→partner) and Y-score (partner→DSCAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KIF4A →	+0.791	+2.169	<.001	<.001	3	7
UCEC	UHRF1 →	+0.684	+1.241	<.001	<.001	3	6
LUAD	CDKN3 →	+0.722	+1.893	.001	<.001	3	6
LUAD	NEK2 →	+0.949	+4.087	<.001	<.001	3	6
LUAD	HJURP →	+1.030	+2.169	<.001	<.001	3	6
STAD	CHAF1B →	+0.562	+2.956	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,831 associations by consensus.

KIF4A by DSCAM expression — LUAD

Explore this box plot interactively →