DSCAM

Across TCGA pan-cancer cohorts, DSCAM RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated DSCAM data layer compared with 11 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DSCAM RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DSCAM expression acts as an unfavorable survival marker, although some lineages such as SCLC and LGG show a favorable association.

HNSC, SCLC, and LGG are the cancer types where DSCAM RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.582	0.755	<.001	53	view →
SCLC	OS	Median	III,IV	0.617	0.260	.001	41	view →
LGG	OS	Median	All	0.929	0.856	<.001	34	view →
LUSC	OS	Tertile	All	0.702	0.808	.015	28	view →
MESO	OS	Tertile	All	0.263	0.524	.003	22	view →
PAAD	DFS	Tertile	All	0.519	0.203	.006	20	view →
TGCT	DFS	Median	All	0.560	0.776	.008	18	view →
CESC	DFS	Median	All	0.647	0.797	.003	16	view →
ESCA	DFS	Tertile	II,III,IV	1.000	0.272	.013	16	view →
BLCA	OS	Median	All	0.304	0.503	.012	13	view →
LUAD	OS	Tertile	All	0.752	0.570	.005	13	view →
LIHC	DFS	Tertile	All	0.354	0.590	.002	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

DSCAM–HNSC (DFS)

Open the HNSC breakdown →