DSCAM

Across TCGA cell cohorts, DSCAM mutation is significantly associated with the RNA expression of many other genes, with 1,260 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DSCAM-associated genes across cancer lineages are ANKRD36B, RPRD1A, and MMS22L. Each is linked with DSCAM in more than 2 cancer types. Because this analysis shows association rather than direction, both DSCAM-to-partner and partner-to-DSCAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD36B grouped by DSCAM-low versus DSCAM-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSCAM→partner) and Y-score (partner→DSCAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ANKRD36B →	+0.550	+2.621	.005	.003	3	3
LARGE_INTESTINE	RPRD1A →	+0.687	+3.584	<.001	<.001	3	3
LARGE_INTESTINE	MMS22L →	+0.690	+1.714	.001	.006	3	3
LARGE_INTESTINE	NAE1 →	+0.478	+2.584	.002	.002	3	3
LARGE_INTESTINE	OR2T8 →	+0.106	+1.693	.001	.003	3	3
LARGE_INTESTINE	YTHDC2 →	+0.581	+1.628	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,260 associations by consensus.

ANKRD36B by DSCAM expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →