DSCAM-AS1

Across TCGA pan-cancer cohorts, DSCAM-AS1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated DSCAM-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DSCAM-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DSCAM-AS1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and COAD show a favorable association.

KIRC, ACC, and BLCA are the cancer types where DSCAM-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.541	0.686	<.001	116	view →
ACC	OS	Tertile	All	0.482	0.912	<.001	108	view →
BLCA	OS	Tertile	All	0.509	0.637	.023	54	view →
KIRP	OS	Tertile	All	0.419	0.756	.001	45	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	36	view →
ESCA	DFS	Median	III,IV	0.574	0.304	.001	21	view →
COAD	DFS	Tertile	II,III,IV	0.807	0.637	.020	18	view →
LGG	OS	Tertile	All	0.942	0.852	.004	12	view →
STAD	OS	Tertile	IV	0.855	0.323	.023	9	view →
HNSC	OS	Tertile	All	0.578	0.341	.024	9	view →
SKCM	OS	Tertile	All	0.178	0.330	.029	6	view →
PRAD	DFS	Tertile	All	0.915	0.968	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

DSCAM-AS1–KIRC (DFS)

Open the KIRC breakdown →