DSC3

Across TCGA cell cohorts, DSC3 mutation is significantly associated with the RNA expression of many other genes, with 254 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DSC3-associated genes across cancer lineages are ADCY10, ST8SIA3, and GNAT3. Each is linked with DSC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DSC3-to-partner and partner-to-DSC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADCY10 grouped by DSC3-low versus DSC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSC3→partner) and Y-score (partner→DSC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADCY10 →	+0.148	+3.131	<.001	.008	3	2
BLOOD_Myeloma	ST8SIA3 →	+0.053	+4.807	<.001	.006	3	1
BLOOD_Myeloma	GNAT3 →	+0.030	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SMIM28 →	+0.023	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SPRR5 →	+0.320	+4.807	<.001	.006	3	1
STOMACH	OR4S2 →	+0.020	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 254 associations by consensus.

ADCY10 by DSC3 expression — LARGE_INTESTINE

Explore this box plot interactively →