DSC2

Across TCGA cell cohorts, DSC2 mutation is significantly associated with the RNA expression of many other genes, with 62 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DSC2-associated genes across cancer lineages are C9orf92, PRELP, and CPA3. Each is linked with DSC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DSC2-to-partner and partner-to-DSC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by DSC2-low versus DSC2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSC2→partner) and Y-score (partner→DSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C9orf92 →	+0.071	+2.347	<.001	<.001	3	2
BLOOD_Leukemia	PRELP →	+0.066	+3.926	<.001	.003	3	2
BLOOD_Myeloma	CPA3 →	+0.024	+3.906	.009	.007	3	1
BLOOD_Myeloma	PTCHD1 →	+0.018	+4.700	<.001	<.001	3	1
BLOOD_Myeloma	HTR3A →	+0.029	+3.716	.003	.005	3	1
SOFT_TISSUE	POTEB →	+0.072	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

C9orf92 by DSC2 expression — SKIN

Explore this box plot interactively →