DSC1

Across TCGA patient cohorts, DSC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,772 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible DSC1-associated proteins across cancer lineages are DSC2, SIN3A_S832, and LRRC8A. Each is linked with DSC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both DSC1-to-partner and partner-to-DSC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DSC1 versus DSC2 in LSCC, with a Pearson correlation of 0.58.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DSC1→partner) and Y-score (partner→DSC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DSC2 →	+0.917	+0.884	<.001	<.001	3	6
HNSC	SIN3A_S832 →	-0.417	-2.562	<.001	<.001	3	3
LSCC	LRRC8A →	+0.347	+0.967	<.001	.003	3	3
LUAD	MANF →	-0.424	-0.097	<.001	.003	3	3
LSCC	NLRX1 →	+0.303	+0.858	.001	.001	3	3
BRCA	PARD6G_S110 →	+0.653	+0.441	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,772 associations by consensus.

DSC1 vs DSC2 — LSCC

Explore this scatter interactively →