DSC1

Across TCGA patient cohorts, DSC1 mutation is significantly associated with the RNA expression of many other genes, with 3,981 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSC1-associated genes across cancer lineages are HSPA9, NARS1, and UQCRH. Each is linked with DSC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both DSC1-to-partner and partner-to-DSC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPA9 grouped by DSC1-low versus DSC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSC1→partner) and Y-score (partner→DSC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPA9 →	+0.450	+2.279	<.001	<.001	3	4
UCEC	NARS1 →	+0.361	+1.688	.002	.001	3	4
BLCA	UQCRH →	+0.497	+2.620	.006	.005	2	5
SKCM	NDUFS4 →	+0.236	+1.106	.009	.002	3	4
UCEC	TAF9 →	+0.596	+3.480	<.001	<.001	3	3
LUAD	RGN →	-1.152	-3.441	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,981 associations by consensus.

HSPA9 by DSC1 expression — UCEC

Explore this box plot interactively →