DROSHA

Across TCGA patient cohorts, DROSHA mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DROSHA-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and MEK1. Each is linked with DROSHA in more than 2 cancer types. Because this analysis shows association rather than direction, both DROSHA-to-partner and partner-to-DROSHA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DROSHA-low versus DROSHA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DROSHA→partner) and Y-score (partner→DROSHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.092	+3.169	.002	.018	3	3
UCEC	EGFR_pY1068 →	-0.172	-1.206	.012	.009	3	2
UCEC	MEK1 →	+0.316	+1.540	.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.100	-1.834	.014	.007	3	2
UCEC	Annexin-1 →	+0.373	+1.341	.010	.017	3	2
UCEC	ASNS →	+0.282	+1.321	.004	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Caspase-7-cleavedD198 by DROSHA expression — COAD

Explore this box plot interactively →