DROSHA

Across TCGA pan-cancer cohorts, DROSHA RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated DROSHA data layer compared with 8 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher DROSHA RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DROSHA expression acts as an unfavorable survival marker, although some lineages such as KIRC and GBM show a favorable association.

MESO, LIHC, and UVM are the cancer types where DROSHA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Quartile	All	0.233	0.528	<.001	99	view →
LIHC	DFS	Median	All	0.463	0.617	<.001	56	view →
UVM	DFS	Tertile	All	0.480	1.000	<.001	51	view →
KICH	DFS	Quartile	All	0.642	1.000	.004	35	view →
CESC	DFS	Tertile	All	0.646	0.823	.002	32	view →
KIRC	DFS	Median	All	0.860	0.730	.009	32	view →
ACC	DFS	Quartile	All	0.332	0.710	.015	22	view →
GBM	DFS	Quartile	All	0.537	0.199	<.001	21	view →
PAAD	DFS	Quartile	All	0.602	0.334	.004	19	view →
LGG	DFS	Tertile	All	0.610	0.374	.003	18	view →
UCEC	DFS	Tertile	All	0.572	0.759	.002	18	view →
SARC	DFS	Tertile	All	0.436	0.739	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

DROSHA–MESO (DFS)

Open the MESO breakdown →