DROSHA

Across TCGA cell cohorts, DROSHA mutation is significantly associated with the RNA expression of many other genes, with 405 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DROSHA-associated genes across cancer lineages are CCDC172, ASZ1, and KCNJ5. Each is linked with DROSHA in more than 1 cancer types. Because this analysis shows association rather than direction, both DROSHA-to-partner and partner-to-DROSHA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC172 grouped by DROSHA-low versus DROSHA-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DROSHA→partner) and Y-score (partner→DROSHA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CCDC172 →	+0.023	+4.108	.004	.005	3	2
LUNG_SCLC	ASZ1 →	+0.034	+2.847	.002	.009	3	2
SKIN	KCNJ5 →	+0.079	+3.624	.004	.005	3	2
OVARY	OR2M4 →	+0.070	+4.700	<.001	.002	3	2
LARGE_INTESTINE	C1QBP →	+0.723	+2.351	<.001	.001	3	2
LARGE_INTESTINE	ATPAF1 →	+0.653	+2.949	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 405 associations by consensus.

CCDC172 by DROSHA expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →