DRD5

Across TCGA patient cohorts, DRD5 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DRD5-associated genes across cancer lineages are Lck, Rad50, and ATM. Each is linked with DRD5 in more than 2 cancer types. Because this analysis shows association rather than direction, both DRD5-to-partner and partner-to-DRD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by DRD5-low versus DRD5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRD5→partner) and Y-score (partner→DRD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Lck →	+0.462	+2.195	.001	.034	3	3
UCEC	Rad50 →	-0.232	-2.308	.001	.005	3	3
UCEC	ATM →	-0.624	-2.369	<.001	<.001	3	3
COAD	INPP4B →	-0.477	-3.313	.006	.010	3	2
COAD	TIGAR →	+0.477	+3.330	.010	.005	3	2
UCEC	EGFR_pY1068 →	-0.208	-1.241	.004	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Lck by DRD5 expression — COAD

Explore this box plot interactively →