DRD5

Across TCGA pan-cancer cohorts, DRD5 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of DRD5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DRD5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DRD5 is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

HNSC, KICH, and PRAD are the cancer types where DRD5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DRD5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.437	<.001	10	view →
KICH	Male	II,III,IV	−0.026	.003	6	view →
PRAD	All	All	−0.190	.007	2	view →
BLCA	All	All	+0.146	.042	2	view →
STAD	All	All	+0.094	.009	2	view →
KIRP	All	IV	+0.077	.028	2	view →
THCA	Female	All	+0.016	.034	2	view →
KIRC	All	IV	−0.028	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

DRD5–HNSC

Open the HNSC breakdown →