DRD5

Across TCGA cell cohorts, DRD5 RNA expression is significantly associated with the go_rna of many other GO terms, with 353 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DRD5-associated GO terms across cancer lineages are Vascular endothelial growth factor receptor-2 signaling pathway, Cellular response to nutrient levels, and Protein quality control for misfolded or incompletely synthesized proteins. Each is linked with DRD5 in more than 4 cancer types. Because this analysis shows association rather than direction, both DRD5-to-partner and partner-to-DRD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vascular endothelial growth factor receptor-2 signaling pathway grouped by DRD5-low versus DRD5-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DRD5→partner) and Y-score (partner→DRD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Vascular endothelial growth factor receptor-2 signaling pathway →	+0.171	+0.028	.009	.008	3	5
CNS	Cellular response to nutrient levels →	+0.045	+0.009	<.001	.004	3	4
CNS	Protein quality control for misfolded or incompletely synthesized proteins →	+0.058	+0.005	<.001	.003	3	4
CNS	Response to starvation →	+0.038	+0.005	<.001	.003	3	3
CNS	Cellular response to starvation →	+0.038	+0.004	<.001	.007	3	3
CNS	Sperm flagellum assembly →	-0.028	-0.004	.006	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 353 associations by consensus.

Vascular endothelial growth factor receptor-2 signaling pathway by DRD5 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →