DRD5

Across TCGA cell cohorts, DRD5 mutation is significantly associated with the RNA expression of many other genes, with 467 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DRD5-associated genes across cancer lineages are C20orf85, TEX55, and GIMAP7. Each is linked with DRD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DRD5-to-partner and partner-to-DRD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by DRD5-low versus DRD5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRD5→partner) and Y-score (partner→DRD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.042	+4.969	<.001	.003	3	2
CNS	TEX55 →	+0.037	+4.321	<.001	.009	3	1
CNS	GIMAP7 →	+0.078	+4.169	<.001	.008	3	1
CNS	SMIM28 →	+0.044	+4.321	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR4F4 →	+0.006	+5.472	<.001	<.001	3	1
LUNG_NSCLC_LUAD	KRTAP19-4 →	+0.212	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 467 associations by consensus.

C20orf85 by DRD5 expression — BLOOD_Leukemia

Explore this box plot interactively →