DRC3

Across TCGA cell cohorts, DRC3 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DRC3-associated genes across cancer lineages are SPIC, TBX22, and ENPP6. Each is linked with DRC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DRC3-to-partner and partner-to-DRC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPIC grouped by DRC3-low versus DRC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRC3→partner) and Y-score (partner→DRC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPIC →	+0.177	+2.925	<.001	.007	3	2
LARGE_INTESTINE	TBX22 →	+0.026	+3.217	<.001	.006	3	1
LARGE_INTESTINE	ENPP6 →	+0.037	+3.115	<.001	.004	3	1
LARGE_INTESTINE	CFAP47 →	+0.196	+3.716	.004	.003	3	1
LARGE_INTESTINE	OR1L6 →	+0.015	+3.700	<.001	.009	3	1
LARGE_INTESTINE	KRTAP5-3 →	+0.026	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

SPIC by DRC3 expression — LARGE_INTESTINE

Explore this box plot interactively →