DRAM1

Across TCGA cell cohorts, DRAM1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DRAM1-associated genes across cancer lineages are OOSP4A, FUT5, and SSMEM1. Each is linked with DRAM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DRAM1-to-partner and partner-to-DRAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OOSP4A grouped by DRAM1-low versus DRAM1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRAM1→partner) and Y-score (partner→DRAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OOSP4A →	+0.053	+4.930	<.001	.008	3	1
LARGE_INTESTINE	FUT5 →	+0.027	+3.920	<.001	.005	3	1
LARGE_INTESTINE	SSMEM1 →	+0.027	+3.707	.001	.009	3	1
LARGE_INTESTINE	KRTAP5-3 →	+0.037	+4.217	<.001	.001	3	1
LARGE_INTESTINE	RNF212B →	+0.111	+3.678	<.001	.009	3	1
LARGE_INTESTINE	ADAM7 →	+0.005	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OOSP4A by DRAM1 expression — SOFT_TISSUE

Explore this box plot interactively →