DRAM1

Across TCGA pan-cancer cohorts, DRAM1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of DRAM1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DRAM1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DRAM1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where DRAM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DRAM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.074	<.001	12	view →
HNSC	Female	III,IV	+1.748	<.001	11	view →
KIRP	All	II,III,IV	+1.256	<.001	11	view →
THCA	Male	All	+1.422	<.001	10	view →
LUSC	Female	All	−2.590	<.001	9	view →
LUAD	Female	III,IV	−1.864	<.001	9	view →
LIHC	Female	II,III,IV	+1.493	<.001	9	view →
COAD	Male	III,IV	+1.241	<.001	9	view →
KICH	All	II,III,IV	−1.249	<.001	6	view →
STAD	Male	II,III,IV	+1.245	<.001	6	view →
CHOL	Female	All	+3.113	<.001	5	view →
READ	Male	All	+2.093	.021	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

DRAM1–KIRC

Open the KIRC breakdown →