DPYS

Across TCGA patient cohorts, DPYS mutation is significantly associated with the RNA expression of many other genes, with 2,375 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPYS-associated genes across cancer lineages are NME1-NME2, NUSAP1, and TIPIN. Each is linked with DPYS in more than 3 cancer types. Because this analysis shows association rather than direction, both DPYS-to-partner and partner-to-DPYS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NME1-NME2 grouped by DPYS-low versus DPYS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPYS→partner) and Y-score (partner→DPYS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NME1-NME2 →	+0.642	+3.480	<.001	.002	3	4
UCEC	NUSAP1 →	+0.858	+3.732	.001	<.001	3	4
UCEC	TIPIN →	+0.585	+4.108	<.001	<.001	3	4
UCEC	PRIM1 →	+0.712	+2.354	.002	.003	3	4
UCEC	WDR76 →	+1.013	+4.108	<.001	<.001	2	4
LUAD	CDKN3 →	+1.192	+3.459	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,375 associations by consensus.

NME1-NME2 by DPYS expression — UCEC

Explore this box plot interactively →