Across TCGA patient cohorts, DPYD mutation is significantly associated with the RNA expression of many other genes, with 6,153 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DPYD-associated genes across cancer lineages are CHEK1, BUB3, and MAD2L1. Each is linked with DPYD in more than 3 cancer types. Because this analysis shows association rather than direction, both DPYD-to-partner and partner-to-DPYD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPYD→partner) and Y-score (partner→DPYD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHEK1 →	+0.561	+1.771	<.001	<.001	3	4
UCEC	BUB3 →	+0.403	+2.276	<.001	<.001	3	4
UCEC	MAD2L1 →	+0.549	+1.771	.001	<.001	3	4
UCEC	SKA3 →	+0.543	+1.606	<.001	<.001	3	4
SKCM	ATP23 →	+0.296	+0.949	.006	.002	3	4
UCEC	CEP76 →	+0.259	+2.191	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,153 associations by consensus.

Exploration

DPYD survival (RNA) · tumor vs normal (RNA) · all DPYD data types